Expression and significance of Bcl-2、VEGF and nm23-H1 gene in non-small cell lung cancer

Objective To explore the relationship among the expression of Bcl-2、VEGF and nm23-H1 gene and lymph node metastasis of lung cancer.Methods Using immunohistochemical technique S-P method,123 patients with lung cancer were examined.Results The positive rate of Bcl-2 oncoprotein expression is significant in the high、middle and low differentiation of lung cancer(P0.05),and so do the P-TNM stageing of lung cancer(P0.05).The group without the lymph node metastasis was significantly different from the group of lymph node metastasis in the positive rate of nm23-H1 oncoprotein(P0.05).The positive rate of VEGF protein expression is significant in the pathological grade and the clinical staging and lymph node metastasis of lung cancer(P0.05).As the same time,the relationship was not found between the expression of Bcl2、VEGF and nm23-H1 oncoprotein of lung cancer.Conclusion Bcl-2、VEGF and nm23-H1 has an important significance on development of lung cancer.The detection of their gene protein has positive effect on diagnosis and treatment of lung cancer.