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2011•Journal of Brain and Nervous DiseasesRequires access

VEGF gene variations in Chinese Han population

Jia Jian-pin

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Abstract

Objective To investigate the vascular endothelial growth factor(VEGF) gene variations in the promoter region in Chinese Han population.Methods The polymorphisms of 300 Chinese Han healthy individuals from Northern China were analyzed using the method of polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP) or direct sequencing.The commercial statistics package SPPS11.5 was used to compare the distribution of the allele and the genotype,and to analyze their correlations with the data on European reported.Results Significant differences were observed between European and Chinese Han healthy individuals with regards to the frequencies of the genotype and allele for-2578C/A and-1154G/A(P 0.01) Conclusion The frequency of-2578A/A,-1154G/G genotypes in Chinese Han population is significantly lower than that in European.

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What this paper is about

Objective To investigate the vascular endothelial growth factor(VEGF) gene variations in the promoter region in Chinese Han population.Methods The polymorphisms of 300 Chinese Han healthy individuals from Northern China were analyzed using the method of polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP) or direct sequencing.The commercial statistics package SPPS11.5 was used to compare the distribution of the allele and the genotype,and to analyze their correlations with the data on European reported.Results Significant differences were observed between European and Chinese Han healthy individuals with regards to the frequencies of the genotype and allele for-2578C/A and-1154G/A(P 0.01) Conclusion The frequency of-2578A/A,-1154G/G genotypes in Chinese Han population is significantly lower than that in European.

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Available abstract

Objective To investigate the vascular endothelial growth factor(VEGF) gene variations in the promoter region in Chinese Han population.Methods The polymorphisms of 300 Chinese Han healthy individuals from Northern China were analyzed using the method of polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP) or direct sequencing.The commercial statistics package SPPS11.5 was used to compare the distribution of the allele and the genotype,and to analyze their correlations with the data on European reported.Results Significant differences were observed between European and Chinese Han healthy individuals with regards to the frequencies of the genotype and allele for-2578C/A and-1154G/A(P 0.01) Conclusion The frequency of-2578A/A,-1154G/G genotypes in Chinese Han population is significantly lower than that in European.

Key concepts: Genotype, Han chinese, Chinese population, Allele, Genetics, Biology, Polymorphism (computer science), Gene

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