Expression and its significance of MMP-3 and TIMP-3 in human brain glioma

Objective To observe the expression of matrix metalloproteinases-3(MMP-3) and its inhibitors(TIMP-3) in human brain glioma and its relationship with glioma grade and invasion.Methods Used the immunohistochemistry SP methods to detect the expression of MMP-3 and TIMP-3 in glioma and normal brain tissues.Results The MMP-3 and TIMP-3 were obviously expressed in the cytoplasm of glioma and endotheliocyte.Part of them were relatively concentrated in the vicinity of tumor.In the group of tumor,the expression rate of MMP-3 was 72.0% and was higher than the control group, the difference was statistically significant(P0.05).Its expression became higher when their malignancy became higher.there was positive correlation between them.The expression rate of TIMP-3 was 56.0% and was higher than was the control group,the difference was statistically significant(P0.05).Its expression does not became higher when their malignancy became higher.There was no obvious correlation between them.Conclusion The expression of MMP-3 and TIMP-3 are related with the malignancy and invasion of glioma,may provide some guidance for the malignancy and treatment in clinic.