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2010•Zhonghua linchuang mianyi he biantai fanying zazhiRequires access

Relationship between Ubiquitin Ligase and Connective Tissue Diseases

Wei Zhou

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Abstract

The ubiquitin (UB) pathway is essential for the degradation of a cellular protein. Ubiquitination of a protein is carried out by a series of enzymatic activities with involvement of ubiquitin-activating enzyme ( E1) , ubiquitin conjugating enzyme ( E2) , and ubiquitin ligase ( E3) to form an ubiquitin-conjugating protein complex. With the ubiquitination process, either the function of the protein will be modified or the protein will be directly degraded by proteasome. In the ubiquitin-proteasome system, E3 plays a key role in the ubiquitination because it can recognize the specific protein substrates of an E2 complex and then catalyzes the UB conjugation to the substrates. In this review, the role of ubiquitin ligase which includes SSA/Ro52, roquin and synoviolin, in connective tissue diseases is discussed.

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What this paper is about

The ubiquitin (UB) pathway is essential for the degradation of a cellular protein. Ubiquitination of a protein is carried out by a series of enzymatic activities with involvement of ubiquitin-activating enzyme ( E1) , ubiquitin conjugating enzyme ( E2) , and ubiquitin ligase ( E3) to form an ubiquitin-conjugating protein complex. With the ubiquitination process, either the function of the protein will be modified or the protein will be directly degraded by proteasome. In the ubiquitin-proteasome system, E3 plays a key role in the ubiquitination because it can recognize the specific protein substrates of an E2 complex and then catalyzes the UB conjugation to the substrates. In this review, the role of ubiquitin ligase which includes SSA/Ro52, roquin and synoviolin, in connective tissue diseases is discussed.

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Available abstract

The ubiquitin (UB) pathway is essential for the degradation of a cellular protein. Ubiquitination of a protein is carried out by a series of enzymatic activities with involvement of ubiquitin-activating enzyme ( E1) , ubiquitin conjugating enzyme ( E2) , and ubiquitin ligase ( E3) to form an ubiquitin-conjugating protein complex. With the ubiquitination process, either the function of the protein will be modified or the protein will be directly degraded by proteasome. In the ubiquitin-proteasome system, E3 plays a key role in the ubiquitination because it can recognize the specific protein substrates of an E2 complex and then catalyzes the UB conjugation to the substrates. In this review, the role of ubiquitin ligase which includes SSA/Ro52, roquin and synoviolin, in connective tissue diseases is discussed.

Key concepts: Ubiquitin ligase, Ubiquitin, Proteasome, Ubiquitin-conjugating enzyme, Ubiquitin-Protein Ligases, DDB1, F-box protein, DNA ligase

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