Analysis on second-line drug resistance situation of multiple drug resistant tuberculosis in Zhejiang,China

Objective To investigate mycobacterium tuberculosis drug resistance to second-line drugs in Zhejiang and provide a scientific basis for the prevention and control of drug-resistant TB epidemic.Methods We randomly selected 30 counties for the study.Samples from the selected counties were entered into the group of surveillance if the specimens were smear-positive.The procedures of mycobacterium isolation,culture and primary species identification were performed under the guidelines of the Laboratory Procedure of Diagnostic Bacteriology in Tuberculosis.Results The surveillance group had 1 077 smear-positive tuberculosis specimens.Among multiple drug resistant(MDR) cases,the rates of anti-tuberculosis drug resistance to second-line drugs were 9.62%,11.54%,7.69%,5.77%,28.85% and 32.69% respectively for kanamycin(K),capreomycin(CPM),amikacin(AK),cycloserine(CS),ofloxacin(OFLX) and para-Aminosalicylate(PAS).The extensive drug resistance(XDR) rate of MDR cases was 3.85%.Conclusion Tuberculosis drug resistance to second-line drugs was in a serious situation in Zhejiang.We should enhance the implementation quality of Directly Observed Treatment Short-course(DOTS),strengthen the detection capability of MDR and XDR,as well as improve the medical treatment comprehensive system for drug resistance TB.