2006•Unpublished venueRequires access

Expression of Nav1.8 in rat dorsal root ganglion neurons under different culture conditions

Hong Zhang

Abstract

Objective:To investigate the expression of Nav1.8 in rat dorsal root ganglion(DRG) neurons under different(culture) conditions.Methods:By use of RT-PCR we observed the role of different blood serum and exogenous nerve growth factor(NGF) on the expression of Nav1.8 in rat DRG neurons.Results:NGF treatment can significantly upregulate the expression of Nav1.8 in the FBS+NGF group and HS+NGF group compared with the FBS and HS groups,while the Nav1.8 mRNA level showed no significant deference between FBS and HS groups.Conclusion:Exogenous NGF can upregulate the expression of(Nav1.8) in cultured rat DRG neuron,while serum of FBS or HS do not affect the growth of the neuron and the expression of Nav1.8.

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Key concepts: Dorsal root ganglion, Nerve growth factor, Downregulation and upregulation, Dorsum, Neuron, Messenger RNA, Internal medicine, Endocrinology