The implantation of esophageal stent with radioactive ~(125)I particles for advanced esophageal carcinomas:observation of therapeutic results

Objective To investigate the therapeutic effect of the implantation of esophageal stent with radioactive ~(125)Ⅰ particles in treating advanced esophageal carcinomas in aged patients.Methods During the period from Sep.2009 to Dec.2010,implantation of esophageal stent was used to treat 43 aged patients with advanced esophageal cancer.Based on the patient's free will,the patients were divided into study group(n = 18) receiving stent with ~(125)Ⅰ particles and control group(n = 25) receiving ordinary stent without ~(125)Ⅰ particles.No significant difference in the age,the lesion length,the degree of stenosis and the disease stage existed between the study group and the control group.The technical success rate,the remission rate of dysphagia,the occurrence of complications and the mean survival time were calculated and analyzed.The results were compared between the two groups.Results The technical success rate was 100% in both groups.The short-term remission rate of dysphagia was also 100% in both groups.The mean survival time in the study group and in the control group was 9.8 months and 4.8 months respectively,the difference between the two groups was statistically significant(P 0.01).No significant difference in the occurrence of postoperative pain and esophageal restenosis existed between the two groups(P 0.05).Conclusion This results of study indicate that for the treatment of advanced esophageal carcinomas the implantation of esophageal stent with radioactive ~(125)Ⅰ particles can surely and markedly prolong the patient's survival time and relive the symptom of dysphagia.This technique is safe,feasible and effective in clinical practice.The use of the stent with radioactive ~(125)Ⅰ particles is superior to the use of the traditional stent in treating patients with advanced esophageal cancer.