Acute pancreatitis accompanied with liver function damage: a clinical observation of 207 cases.

Objective To investigate the clinical profiles, pathogenesis and prognosis prediction of patients with acute pancreatitis and liver function damage. Methods Two hundred and seven patients of acute pancreatitis and liver function damage were grouped according to etiopathogenisis, severity of disease and, and patients′ age. The severity of liver function damage, prognosis and turnover of each group were compared; the liver function indices, which are more sensitive and more specific in predicting the severity of acute pancreatitis were analyzed. Results The severity of liver function damages in severe acute pancreatitis (SAP) patients was higher than that in mild acute pancreatitis (MAP) patients(P 0.05). The liver function indices such as ALT, ALP, LDH in biliary acute pancreatitis (BAP) were worse than those in non-biliary acute pancreatitis (NAP)(P 0.05). Patients with BAP were tended to have severe acute pacreatitis than patients with NAP did; moreover, BAP patients had higher operation rate, higher mortality, and longer hospitalization. There was no difference in severity of liver function damage between patients of different ages groups(P 0.05). ALT, AST, and LDH had high sensitivity and specificity in predicting acute pancreatitis severity. Conclusions Patients with BAP have obvious liver function damage. ALT, AST, and LDH might be used in predicting the severity of acute pancreatitis.