Antimicrobial activity of Gemini antimicrobial agents with different chemical structure

To obtain strong activity antimicrobial agent,the antimicrobial properties of Gemini antimicrobial agents(C1,C2,C3 and C4) were evaluated by quantifying the minimal inhibitory concentration(MIC),n-dodecyl-trimethylammonium bromide(DTAB) as a comparison.The results indicated that these Gemini antimicrobial agents against S.aurueus,E.coli and C.albicans were superior to DTAB.The MIC of C2 against S.aurueus and E.coli were 1.5 μg·L-1 and 3.91 μg·L-1,respectively.The MIC of C4 against C.albicans was 3.91 μg·L-1.these Gemini antimicrobial agents exhibited improved activity against a broad spectrum of Gram-positive and Gram-negative bacteria as well as yeast.Their antimicrobial properties rely on the Gemini molecular structures with longer length of main-chain,full-chain and R groups,their antimicrobial activities are stronger,and fluorinated alkyl groups can markedly improve their antimicrobial properties compared with the same hydrocarbon one.