2009•Chinese Journal of Current Advances in General SurgeryRequires access
Expression of chemokine receptor CCR7 and CXCR4 in human colorectal carcinoma and its significance
Yinlu Ding
Open publisher page 0 citations
Abstract
Objective:To observe the expression of chemokine receptor CCR7 and CXCR4 in human colorectal carcinoma and its significance,so as to assess their expression with the metastasis and prognosis of colorectal carcinoma. Methods:Immunohistochemistry was used to detect the expression of chemokine receptor CCR7 and CXCR4 in 110 patients with colon cancer.The relationship between the CCR7 and CXCR4 expression and the clinic pathological characters was statistically analyzed. Results:CCR7 and CXCR4 expression were positively expressed in 59.1% and 45.5%of the patients. The high expression rate of CCR7 and CXCR4 in lymph node metastasis positive cases was 81. 5% and 60.0% respectively,but the without lymph node metastasis positive cases were 26.7% and 24.4% respectively. The positive expression was significantely higher in the patients with lymph node metastasis than those non-lymph node metastasis(P0.005) ,and was also correlated with depth of invasion (P0.005) and TNM stage (P0.01) ,but not with age,gender,tumor size,histological type or different degree. In the retrospective study,the sensitivity,specificity,positive predictive value (PPV) ,negatively predictive value (NPV) of CCR7 express for lymph node metastasis were 90.8%,86.7%,90.8%,86.7%respectively. The sensitivity,specificity,positive predictive value (PPV) ,negatively predictive value (NPV) of CXCR4 express for lymph node metastasis were 69.2%,88.9%,90.0%,66.7%respectively. Receiver operating characteristic (ROC) analysis showed that the accuracy of the combined examination of CXCR4 and CCR7 expression in diagnosing lymph node metastasis was high. Conclusion:The expression of CCR7 and CXCR4 may be related to lymph node metastasis of colon cancer. Moreover,the combined examination of CCR7 and CXCR4 may be useful in predicting lymph node metastasis of colon cancer. Also the expression of CCR7 and CXCR4 could be helpful in prognosis after surgery of patients with colorectal carcinoma.