Clinical observation of fludarabine\mitoxantrone\dexamethasone in refractory low-degree malignant lymphoma

[Objective] To observe the efficacy and safety of fludarabine\mitoxantrone\dexamethasone (FMD regiment) in refractory low-degree malignant lymphoma. [Methods] Fifteen patients with refractory low-degree malignant lymphoma were administered with FMD regiment. [Results] Among fifteen patients, ten had response and the overall response rate was 66.7%, five patients were complete remission (33.3%), five patients were partial remission (33.3%), three patients were stable (20%), and two patients were aggravated (13.3%). All patients had mild adverse effect. [Conclusion] FMD regiment has satisfactory efficacy in the treatment of refractory low-degree malignant lymphoma with mild adverse effect.