2010•Shiyong yaowu yu linchuangRequires access

Regulation of imiquimod on TLR4 in the peripheral blood of patient with condyloma acuminatum.

Liang HanChang, Fan RuiJin, Liang FuGui

Abstract

Objective To study the regulation of imiquimod on TLR4 in the peripheral blood of patients with condyloma acuminatum.Methods Sixteen adult patients with condyloma acuminatum and 16 health control were sequentially enrolled in this study.Serum levels of TLR4mRNA were measured by real-time polymerase chain reaction in 16 cases with condyloma acuminatum before and after treatment with imiquimod for 8 weeks and 16 health control.Results The serum levels of TLR4mRNA before treatment were significantly higher than that of health control(t=10.82,P0.001).Expression of serum TLR4mRNA in condyloma acuminatum was significantly decreased after 8 weeks imiquimod treatment(t=10.74,P0.001),and the serum levels of TLR4mRNA had no significant difference between the 2 groups(t=1.05,P=0.3008).Conclusion TLR4 plays an important role in the development and advance of imiquimod.The results show that imiquimod could inhibit the over expression of TLR4mRNA in patients with condyloma acuminatum.

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Key concepts: Imiquimod, Condyloma Acuminatum, Medicine, Peripheral blood, TLR4, Significant difference, Dermatology, Immunology