Ginkgo biloba extract(EGb 761) enhancing retinal anti-oxidation capability after light-induced retinal damage in rats

Objective To investigate the effect of ginkgo biloba extract(EGb 761) on retinal anti-oxidation capability after light-induced retinal damage(LRD) in rats,and discuss the protective mechanism of EGb 761 on the photoreceptor cells.Methods Twenty-four female Sprague Dawley(SD) rats were randomly divided into normal control group(NC group),LRD model group(model group),LRD model + normal saline group(MN group) and LRD model + EGb 761 group(ME group),6 cases in each group.Rats in MN group and ME were intraperitoneally injected with normal saline and 3.5 g·L-1 EGb 761(100 mg·kg-1)at one week before light exposure.The levels of malondialdehyde(MDA),total superoxide dismutase(T-SOD),glutathione peroxidase(GSH-Px),and catalase(CAT) in the retinal tissues were determined at 24 hours after light exposure.Results At 24 hours after exposure,the MDA levels in the M,MN,ME groups were(33.87±1.19)nM·g-1,(31.13±1.50)nM·g-1 and(24.33±3.23)nM·g-1,significantly higher than that in NC group(20.00±1.99) nM·g-1,there were statistical differences(all P0.05),those in M group and MN group were similar to each other,there was no statistical difference(P0.05),and that of ME group was slightly lower than those in M group and MN group,there were statistical differences(all P0.05).The activities of T-SOD,GSH-Px,and CAT were similar in M group and MN group,there was no statistical difference(all P0.05),but they were significantly lower than those in NC group and ME group,there were statistical differences(all P0.05);Their activities in ME group were significantly lower than those in NC group,there were statistical differences(all P0.05).Conclusion Intraperitoneal injection of EGb 761 can enhance the retinal anti-oxidation capability,thus exert protective effect on photoreceptor cells after LRD.