Curative effect of Mitoxantrone plus Thalidomide and Dexamethasone on treatment of multiple myeloma

Objective To compare the efficacy and toxicity of TD treatment(Thalidomide+Dexamethasone,as control group) and TD plus Mitoxantrone treatment(treatment group) on patients with multiple myeloma(MM).Methods Each of twenty-three patients in treatment group were initially administered Thalidomide at dose of 100 mg/d,then increased 50 mg/d every two days up till 200 mg/d.The regimen also consisted of 4 days of intravenous Dexamethasone(20～40)mg/d and Mitoxantrone 2 mg/d,each cycle lasted for 28 d.Mean while,the twenty-three cases in control group were received chemotherapy with TD regimen alone.Results The total response rate was 78.2%(18/23) and 65.2%(15/23) in treatment group and control group respectively,which demonstrated no significant difference(P0.05).The median time to response(TTR) in treatment group was 36.6 d(30~60)d.While the median TTR in control group was 50.0 d(30~90)d.(P0.05).The adverse effects had no significant differences between two groups.Conclusion The median TTR in Mitoxantrone plus TD regimen group is shorter than that in TD regimen group and the MTD therapy is well tolerated.