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Investigation on pharmacokinetics of home-made lansoprazole

Tang Xin-qiang

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Abstract

Objective To study the pharmacokinetics of home-made lansoprazole,explore the effective HPLC method.Methods The samples were extracted by aether-dichlormethane mixed liquor,then dissociated HypersilBDS C18 chromato bar.Water-acetonitrile-triethylamine was used as mobile phase.Results The linear range of lansoprazole was 0.05~2.0 μg/mL.The minimum concentration was 0.05 μg/mL,the within-day RSD was 1.4%~5.4%.The inter-day RSD was 1.5%~7.8%.The relative recovery was 94%~96%.AUC0t and AUC0∞ were(3.387±1.225) and(3.533±1.237) h · μg/mL respectively;Cmax was(0.918±0.252) μg/mL;Tmax and T1/2 were(1.917±0.583) and(2.081±0.771) h respectively.Conclusion The pharmacokinetics of home-made Lansoprazole is accordance with the literatures.This method is convenient and feasible.

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Objective To study the pharmacokinetics of home-made lansoprazole,explore the effective HPLC method.Methods The samples were extracted by aether-dichlormethane mixed liquor,then dissociated HypersilBDS C18 chromato bar.Water-acetonitrile-triethylamine was used as mobile phase.Results The linear range of lansoprazole was 0.05~2.0 μg/mL.The minimum concentration was 0.05 μg/mL,the within-day RSD was 1.4%~5.4%.The inter-day RSD was 1.5%~7.8%.The relative recovery was 94%~96%.AUC0t and AUC0∞ were(3.387±1.225) and(3.533±1.237) h · μg/mL respectively;Cmax was(0.918±0.252) μg/mL;Tmax and T1/2 were(1.917±0.583) and(2.081±0.771) h respectively.Conclusion The pharmacokinetics of home-made Lansoprazole is accordance with the literatures.This method is convenient and feasible.

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Available abstract

Objective To study the pharmacokinetics of home-made lansoprazole,explore the effective HPLC method.Methods The samples were extracted by aether-dichlormethane mixed liquor,then dissociated HypersilBDS C18 chromato bar.Water-acetonitrile-triethylamine was used as mobile phase.Results The linear range of lansoprazole was 0.05~2.0 μg/mL.The minimum concentration was 0.05 μg/mL,the within-day RSD was 1.4%~5.4%.The inter-day RSD was 1.5%~7.8%.The relative recovery was 94%~96%.AUC0t and AUC0∞ were(3.387±1.225) and(3.533±1.237) h · μg/mL respectively;Cmax was(0.918±0.252) μg/mL;Tmax and T1/2 were(1.917±0.583) and(2.081±0.771) h respectively.Conclusion The pharmacokinetics of home-made Lansoprazole is accordance with the literatures.This method is convenient and feasible.

Key concepts: Lansoprazole, Pharmacokinetics, Cmax, Chemistry, Chromatography, Triethylamine, High-performance liquid chromatography, Acetonitrile

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