Clinical distribution and drug resistance of 2092 strains of Pseudomonas aeruginosa causing nosocomial infections

OBJECTIVE To investigate the clinical distribution and drug resistance of Pseudomonas aeruginosa and to provide the reference for clinical treatment of P.aeruginosa infections.METHODS Various types of specimens were collected from the hospitalized patients from Jul 2007 to Mar 2011,the bacterial culture and identification were performed,the drug susceptibility testing was carried out by Kirby-Bauer method,the statistical analysis of drug resistance was performed by using WHONET 5.4 software.RESULTS A total of 2092 strains of P.aeruginosa were isolated,accounting for 23.3%,among which 1748 strains were isolated from the respiratory tract.Most of the 2092 strains distributed intensively in the ICU,department of cadre ward,department of respiratory internal medicine,department of neurology,and department of neurosurgery,accounting for 84.0%.The antibiotics resistance rate to sulfamethoxazole/trimethoprim was the highest(71.8%),the cefoperazone/sulbactam the lowest(15.6%),the drug resistance rates to imipenem and meropenem were 39.8% and 28.3%,respectively.CONCLUSION To understand the clinical distribution of P.aeruginosa strains and monitor its drug resistance dynamically can guide the reasonable use of antibiotics as well as control and delay the emergence of drug resistant strains.