Observation on Immunogenicity of Liquid Inactivated Vero Cell Rabies Vaccine

Objective To assess the immunogenicity of liquid inactivated vero cell rabies vaccine.Methods The people vaccinated after rabies exposure were enrolled in the study,who had no vaccination history of liquid inactivated vero cell rabies vaccine and dog bite.According to the inclusion criteria and exclusion criteria of the trial protocol,subjects were administered 5 dose liquid inactivated vero cell rabies vaccine.Immunogenicity was assessed before vaccination and at 7 days,14 days,28 days,45 days and 180 days later by taking blood samples to detect neutralizing antibody to rabies virus.Results According inclusion criteria and exclusion criteria,120 subjects were administered 5 dose liquid inactivated vero cell rabies vaccine.They were antibody IgG negative before the vaccination.The seroconversion rate of antibody IgG weas 10.83% at 7 days and was 100% at 14 days after first dose of vaccination.The antibody IgG positive rates were 100% at 28 days,at 45 days after first dose of vaccination and 180 days after immunization program completed.The GMTs were only 0.08IU/ml at 7 days,1.02IU/ml at 14 days and increase of GMT was by 12.75 times after first dose of vaccination.At 28 days and 45 days after first dose of vaccination,the GMTs were 4.93 IU/ml and 9.71 IU/ml,respectively.The increases of GMT at 28 days and 45 days after first dose of vaccination were by 4.83 and 9.52 times than at 14 days after first dose of vaccination,respectively.At 180 days after immunization program completed,the GMT was 6.25 IU/ml.Conclusion The domestic liquid inactivated vero cell rabies vaccine was highly immunogenic.The people who had vaccination history of liquid inactivated vero cell rabies vaccine may not be vaccinated if they were exposed to rabies virus within 6 months.