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2005•Pharmaceutical Journal of Chinese People's Liberation ArmyRequires access

Study on Antibacterial Activity in Vitro of Gatifloxacin and Ciprofloxacinagainst Pathogen from Community Acquired Infections

Pei He

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Abstract

Aim To evaluate the antibacterial activity of gatifloxacin compared with ciprofloxacin against common isolates in vitro.Methods Minimal Inhibitory Concentrations (MIC) were determined by agar dilution method.Results Among G~-,the susceptible rate of K.pneumoniae (ESBLs -),P.aeruginosa,Enterobacter was over 90%,while it was over 70% among E.coli,K.pneumoniae (ESBLs +) and bacillus proteus.The MIC_90 of Acinetobacter and Serratia was 1～2μg·ml~-1.Among G~+,the susceptible rate of gatifloxacin against Staphylococcus (96.2%) was higher than that of ciprofloxacin (88.5%),while Streptococcus was not susceptive to both gatifloxacin and ciprofloxacin.Conclusion Compared with ciprofloxacin,gatifloxacin has a powerful antibacterial activity to pathogen from community acquired infections.

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Aim To evaluate the antibacterial activity of gatifloxacin compared with ciprofloxacin against common isolates in vitro.Methods Minimal Inhibitory Concentrations (MIC) were determined by agar dilution method.Results Among G~-,the susceptible rate of K.pneumoniae (ESBLs -),P.aeruginosa,Enterobacter was over 90%,while it was over 70% among E.coli,K.pneumoniae (ESBLs +) and bacillus proteus.The MIC_90 of Acinetobacter and Serratia was 1～2μg·ml~-1.Among G~+,the susceptible rate of gatifloxacin against Staphylococcus (96.2%) was higher than that of ciprofloxacin (88.5%),while Streptococcus was not susceptive to both gatifloxacin and ciprofloxacin.Conclusion Compared with ciprofloxacin,gatifloxacin has a powerful antibacterial activity to pathogen from community acquired infections.

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Available abstract

Aim To evaluate the antibacterial activity of gatifloxacin compared with ciprofloxacin against common isolates in vitro.Methods Minimal Inhibitory Concentrations (MIC) were determined by agar dilution method.Results Among G~-,the susceptible rate of K.pneumoniae (ESBLs -),P.aeruginosa,Enterobacter was over 90%,while it was over 70% among E.coli,K.pneumoniae (ESBLs +) and bacillus proteus.The MIC_90 of Acinetobacter and Serratia was 1～2μg·ml~-1.Among G~+,the susceptible rate of gatifloxacin against Staphylococcus (96.2%) was higher than that of ciprofloxacin (88.5%),while Streptococcus was not susceptive to both gatifloxacin and ciprofloxacin.Conclusion Compared with ciprofloxacin,gatifloxacin has a powerful antibacterial activity to pathogen from community acquired infections.

Key concepts: Gatifloxacin, Ciprofloxacin, Microbiology, Streptococcus pneumoniae, Antibacterial activity, Pseudomonas aeruginosa, Agar Dilution Method, Minimum inhibitory concentration

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