ScholarLens Back to search
2009•Journal of Contemporary Urologic and Reproductive OncologyRequires access

The expression and signification of hedgehog signaling pathway effective proteins in prostate cancer and para-cancer tissues

Zhang Hai-ya

Open publisher page 0 citations

Abstract

Objective To investigate the expression and significance of some key effective proteins from Hedgehog(Hh) signaling pathway in human prostate carcinoma and para-carcinoma tissues. Methods Utilizing immunohistochemistry essay,the tissue samples from 51 cases prostate carcinoma and paracarcimoma were detected,and the expression of Shh、Ptch1 and Gli1 proteins were statistically analysed. Results The content of Shh、Ptch1 and Gli1 in Pca was markedly elevated compare with their corresponding adjacent normal tissues,the expression of Shh and Ptch1 have positive correlation and this correlation has statistical significance Conclusions The elevate expression of Shh、Ptch1 and Gli1 strongly activate the hedgehog signaling pathway in Pca,Gli1 has potential to be a better diagnostic marker for prostate cancer.

About this research paper

What this paper is about

Objective To investigate the expression and significance of some key effective proteins from Hedgehog(Hh) signaling pathway in human prostate carcinoma and para-carcinoma tissues. Methods Utilizing immunohistochemistry essay,the tissue samples from 51 cases prostate carcinoma and paracarcimoma were detected,and the expression of Shh、Ptch1 and Gli1 proteins were statistically analysed. Results The content of Shh、Ptch1 and Gli1 in Pca was markedly elevated compare with their corresponding adjacent normal tissues,the expression of Shh and Ptch1 have positive correlation and this correlation has statistical significance Conclusions The elevate expression of Shh、Ptch1 and Gli1 strongly activate the hedgehog signaling pathway in Pca,Gli1 has potential to be a better diagnostic marker for prostate cancer.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Objective To investigate the expression and significance of some key effective proteins from Hedgehog(Hh) signaling pathway in human prostate carcinoma and para-carcinoma tissues. Methods Utilizing immunohistochemistry essay,the tissue samples from 51 cases prostate carcinoma and paracarcimoma were detected,and the expression of Shh、Ptch1 and Gli1 proteins were statistically analysed. Results The content of Shh、Ptch1 and Gli1 in Pca was markedly elevated compare with their corresponding adjacent normal tissues,the expression of Shh and Ptch1 have positive correlation and this correlation has statistical significance Conclusions The elevate expression of Shh、Ptch1 and Gli1 strongly activate the hedgehog signaling pathway in Pca,Gli1 has potential to be a better diagnostic marker for prostate cancer.

Key concepts: GLI1, PTCH1, Hedgehog, Hedgehog signaling pathway, Sonic hedgehog, Immunohistochemistry, Cancer, Cancer research

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
The expression and signification of hedgehog signaling pathway effective proteins in prostate cancer and para-cancer tissues — Research Paper | ScholarLens