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2009•Chinese Journal of Hospital PharmacyRequires access

Improvement of test solution preparation for the assay of astragaloside IV from Radix Astragali and its preparations

Zhenyu Li

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Abstract

OBJECTIVE To improve the method of extraction and purification for astragaloside Ⅳ from Radix Astragali and its compound.METHODS The herb was extracted using methanol three times by ultrasonic method first,and then purified using D101 macroporous resin. Finally,the content of astragaloside Ⅳwas determined by HPLC-ELSD.RESULTS Compared with Pharmacopoeia method,the improved method is faster and more convenient,and there is no significant difference in the content of astragaloside Ⅳ determined by the two methods (P0.05).CONCLUSION The improved method is stable,accurate,repeatable,and applicable.

About this research paper

What this paper is about

OBJECTIVE To improve the method of extraction and purification for astragaloside Ⅳ from Radix Astragali and its compound.METHODS The herb was extracted using methanol three times by ultrasonic method first,and then purified using D101 macroporous resin. Finally,the content of astragaloside Ⅳwas determined by HPLC-ELSD.RESULTS Compared with Pharmacopoeia method,the improved method is faster and more convenient,and there is no significant difference in the content of astragaloside Ⅳ determined by the two methods (P0.05).CONCLUSION The improved method is stable,accurate,repeatable,and applicable.

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Available abstract

OBJECTIVE To improve the method of extraction and purification for astragaloside Ⅳ from Radix Astragali and its compound.METHODS The herb was extracted using methanol three times by ultrasonic method first,and then purified using D101 macroporous resin. Finally,the content of astragaloside Ⅳwas determined by HPLC-ELSD.RESULTS Compared with Pharmacopoeia method,the improved method is faster and more convenient,and there is no significant difference in the content of astragaloside Ⅳ determined by the two methods (P0.05).CONCLUSION The improved method is stable,accurate,repeatable,and applicable.

Key concepts: Radix (gastropod), Chromatography, Astragaloside, Chemistry, Extraction (chemistry), High-performance liquid chromatography, Chromatography detector, Biology

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Improvement of test solution preparation for the assay of astragaloside IV from Radix Astragali and its preparations — Research Paper | ScholarLens