RELATIONSHIP OF ANGIOTENSIN CONVERTING ENZYME GENE POLYMORPHISM WITH CORONARY ARTERY DISEASE

Objective: To investigate the association between insertion/deletion polymorphism of the angiotensin converting enzyme (ACE) gene, the presence and number of diseased coronary arteries of coronary artery disease (CAD). Methods: The ACE genotypes were assessed by polymerase chain reaction from genomic dioxyribonucleic acid.The ACE genotypes and theirs allele frequencies of each group were calculated and were compared with each other.The established cadiovascular risk factors and ACE DD genotype for CAD in this study population were analyzed by multiple logistic regression analysis.The presence or absence CAD was determined by angiography (the gold criteria).Results:(1) The frequencies of the ACE DD genotype and D allele in CAD group were higher than that in control group(χ 2=16.04,16.08;P0.01). The unadjusted odds ratio for having coronary artery disease conferred by the D allele in CAD group was 2.15(P0.01) assuming it was recessive and 2.84(P0.01) assuming it was dominant.(2)In the patients with one, two, or three significantly diseased coronary arteries, the DD genotype or their frequencies of the D allele were similar(χ 2=1.50,1.06;P0.05).(3)The multiple logistic regression analysis revealed significant effects on the presence of CAD: The DD genotype of ACE gene is a cardiovascular risk factor.Conclusion:(1)The insertion/deletion polymorphism of the angiotensin converting enzyme gene is associated with the prevalence of coronary artery disease in our study.(2)The ACE D allele and DD genotype of ACE gene are not associated with the number of diseased coronary arteries. (3)The DD genotype of ACE gene is a risk factor in those with coronary artery disease.