Expression of Insulin-Like Growth Factor-1 Receptor mRNA in Human Breast Cancer Tissues and Its Clinical Significance

Objective: To investigate the expression of IGF-1R mRNA in human breast cancer tissues and its prognostic roles.Methods: Semi-quantitative RT-PCR assay was employed to detect the expression of IGF-1R mRNA in 82 breast cancer and correspond-ing normal breast epithelial tissues.Additionally,the correlation of IGF-1R mRNA expression with clinicopathological factors of breast cancer patients was investigated and its correlation with prognosis of breast cancer patients was also investigated.Results: The level of IGF-1R mRNA expression was significantly higher than that in corresponding normal breast epithelial tissues(P0.001).High level of IGF-1R mRNA expression was significantly correlated with tumor differentiation,TNM stage and lymph node metastasis of breast cancer patients(P=0.005,0.025 and 0.041,respectively).The 5-year overall survival rate of breast cancer patients with high IGF-1R mRNA(38.3%) was significantly shorter than that in those patients with low IGF-1R mRNA(49.7%;P=0.009).Multivariate analysis of COX model showed that IGF-1R mRNA expression was an independent prognostic factor for breast cancer patients(HR=2.78,95%CI: 1.94-3.94,P=0.041).Conclusion: The upregulation of IGF-1R mRNA might play important roles in progression of breast cancer and the status of IGF-1R mRNA expression has potential of being an important biomarker for breast cancer patients.