Evaluate the Effect of Preoperative Chemotherapy Oxaliplatin Combined With 5-FU and CF in 28 Patients of Rectal Cancer

Objective To evaluate the effect of preoperative chemotherapy in combination with Oxaliplatin,fluorouracil(5-FU) and Calcium Folinate(CF) in rectal cancer patients.Methods 60 patients with rectal cancer were divided into combined chemotherapy group(28 cases) and simple chemotherapy group(32 cases).The three drugs of Oxaliplatin,5FU and CF were administrated to combined chemotherapy group and the drugs of 5-FU and CF were administrated to simple chemotherapy group before surgery.All patients were treated with three cycles of chemotherapy based on evaluation criteria of the solid tumors according to WHO criterion.Post-operative specimens dissipated by Wheeler Rectal Cancer Regression Grade.The mass tumor efficacy and rectal cancer regression were compared between the two groups.Results The total effective rate of combined chemotherapy group was 64 %(18 cases),and that in the simple chemotherapy group was 19%(6 cases),moreover,there was significant difference in two groups(P 0.05).the total effective rate of mass tumor regression in the combined chemotherapy group was 79%(22 cases),and that in the simple chemotherapy group was 34%(11 cases),the difference between the two groups was significant(P 0.05).Conclusion Combined treatment of Oxaliplatin with 5-FU,CF obviously reduced tumor mass and cancer cell regression than that of chemotherapy with 5-FU and CF.