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Effects of Interleukin-1 on Rheumatoid Arthritis Model Induced by TypeIICollagen

Cai Chunyou

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Abstract

Objective To observe the effect of interleukin-1 (IL-1) on collagen induced arthritis. Methods The multiple arthritis in DBA/1 mice was induced by immunized with native typeⅡcollagen(CⅡ) ;IL-1 was injected intradermally to observe its effect on collagen induced arthritis (CIA) 18 days later. Serum antibody to CⅡwas measured by ELISA. Disease incidence and severity were assessed by clinical index and histological features. Results All of the mice immunized with CⅡdeveloped CIA, but no one immunized with complete freunds adjuvant(CFA) had CIA. The levels of anti CⅡantibody in serum of CIA mice were higher than that in the control. Incidence and severity of CIA in mice treated with IL-1 are more significant than those without treatment. Conclusion CⅡcan induce CIA in DBA/1 mice. The development of CIA in DBA/1 mice was accelerated by IL-1.

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What this paper is about

Objective To observe the effect of interleukin-1 (IL-1) on collagen induced arthritis. Methods The multiple arthritis in DBA/1 mice was induced by immunized with native typeⅡcollagen(CⅡ) ;IL-1 was injected intradermally to observe its effect on collagen induced arthritis (CIA) 18 days later. Serum antibody to CⅡwas measured by ELISA. Disease incidence and severity were assessed by clinical index and histological features. Results All of the mice immunized with CⅡdeveloped CIA, but no one immunized with complete freunds adjuvant(CFA) had CIA. The levels of anti CⅡantibody in serum of CIA mice were higher than that in the control. Incidence and severity of CIA in mice treated with IL-1 are more significant than those without treatment. Conclusion CⅡcan induce CIA in DBA/1 mice. The development of CIA in DBA/1 mice was accelerated by IL-1.

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Available abstract

Objective To observe the effect of interleukin-1 (IL-1) on collagen induced arthritis. Methods The multiple arthritis in DBA/1 mice was induced by immunized with native typeⅡcollagen(CⅡ) ;IL-1 was injected intradermally to observe its effect on collagen induced arthritis (CIA) 18 days later. Serum antibody to CⅡwas measured by ELISA. Disease incidence and severity were assessed by clinical index and histological features. Results All of the mice immunized with CⅡdeveloped CIA, but no one immunized with complete freunds adjuvant(CFA) had CIA. The levels of anti CⅡantibody in serum of CIA mice were higher than that in the control. Incidence and severity of CIA in mice treated with IL-1 are more significant than those without treatment. Conclusion CⅡcan induce CIA in DBA/1 mice. The development of CIA in DBA/1 mice was accelerated by IL-1.

Key concepts: Medicine, Rheumatoid arthritis, Arthritis, Collagen-induced arthritis, Type II collagen, Adjuvant, Immunology, Internal medicine

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