Combination of HbA1c and FPG Examination in Screening of Gestational Diabetes Mellitus

Objective:To evaluate the feasibility of combination of glycosylated hemoglobin A1c(HbA1c)and fasting plasma glucose(FPG) in screening of gestational diabetes mellitus(GOM).Methods Recording to the 75 g oral glucose tolerance test(OGTT) and HbA1c measurement during 24-28 pregnant weeks,198 cases were as assigned into GDM group and 198 cases were assigned into non-GDM group based on the International Association of Diabetes and Pregnancy Study Groups(IADPSG) guidelines.The results of HbA1c,FPG and OGTT between two groups were analyzed.Results:HbA1c level in GDM group was higher than that in non-GDM group(P0.01).The area under receiver operating characteristic(ROC) curve of HbA1c,FPG and OGTT was 0.819,0.795 and 0.831,respectively.When the cut-off value of HbA1c was 5.25%,the sensitivity of results was 74.4%and the specificity was 78.9%.The kappa coefficient for identifying GDM between OGTT and HbA1 c was 0.530(P = 0.000),but 0.608(P = 0.000) if HbA1 c combined with FBG.Conclusions:HbA1 c combined with FPG can be of some value in screening of GDM.