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A Cytosolic Adaptor Protein-FADD

Li Wen

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Abstract

FADD/MORT1 is a cytosolic adaptor protein whi ch is critical for signalling from CD95 (Fas/APO 1) and other members of the tu mour necrosis factor receptor (TNF R) family. Its C terminal death domain binds to the corresponding domain of the death receptor,FADD in turn rec ruits the protease procaspase 8 through homophilic interaction of death effecto r domains and to trigger the apoptosis pathway. Apart from its role in apoptosis, mouse gene knockout studies have indicated that FADD is also involved in other biology processes.

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What this paper is about

FADD/MORT1 is a cytosolic adaptor protein whi ch is critical for signalling from CD95 (Fas/APO 1) and other members of the tu mour necrosis factor receptor (TNF R) family. Its C terminal death domain binds to the corresponding domain of the death receptor,FADD in turn rec ruits the protease procaspase 8 through homophilic interaction of death effecto r domains and to trigger the apoptosis pathway. Apart from its role in apoptosis, mouse gene knockout studies have indicated that FADD is also involved in other biology processes.

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Available abstract

FADD/MORT1 is a cytosolic adaptor protein whi ch is critical for signalling from CD95 (Fas/APO 1) and other members of the tu mour necrosis factor receptor (TNF R) family. Its C terminal death domain binds to the corresponding domain of the death receptor,FADD in turn rec ruits the protease procaspase 8 through homophilic interaction of death effecto r domains and to trigger the apoptosis pathway. Apart from its role in apoptosis, mouse gene knockout studies have indicated that FADD is also involved in other biology processes.

Key concepts: FADD, Death domain, Signal transducing adaptor protein, Fas receptor, Cell biology, Cytosol, Apoptosis, Biology

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