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2015•Progress in Microbiology and ImmunologyRequires access

The effects of TIMP-1 and hepatic stellate cells on liver fibrosis

Tang Mei-yin

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Abstract

Liver fibrosis,which is the only way from chronic liver disease to cirrhosis,is the result of extracellular matrix(ECM) excessive deposition in the liver. The ECM is mainly synthesized by the activated hepatic stellate cells(HSC),and its degradation is regulated by the matrix metalloproteinase tissue inhibitor-1(TIMP-1),therefore HSC and TIMP-1 play important roles on development of hepatic fibrosis. Recently,antifibrotic studies about HSC and TIMP-1 have been a hot spot,this article reviewed the biological characteristics of HSC and TIMP-1 and their effects on liver fibrosis.

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What this paper is about

Liver fibrosis,which is the only way from chronic liver disease to cirrhosis,is the result of extracellular matrix(ECM) excessive deposition in the liver. The ECM is mainly synthesized by the activated hepatic stellate cells(HSC),and its degradation is regulated by the matrix metalloproteinase tissue inhibitor-1(TIMP-1),therefore HSC and TIMP-1 play important roles on development of hepatic fibrosis. Recently,antifibrotic studies about HSC and TIMP-1 have been a hot spot,this article reviewed the biological characteristics of HSC and TIMP-1 and their effects on liver fibrosis.

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Available abstract

Liver fibrosis,which is the only way from chronic liver disease to cirrhosis,is the result of extracellular matrix(ECM) excessive deposition in the liver. The ECM is mainly synthesized by the activated hepatic stellate cells(HSC),and its degradation is regulated by the matrix metalloproteinase tissue inhibitor-1(TIMP-1),therefore HSC and TIMP-1 play important roles on development of hepatic fibrosis. Recently,antifibrotic studies about HSC and TIMP-1 have been a hot spot,this article reviewed the biological characteristics of HSC and TIMP-1 and their effects on liver fibrosis.

Key concepts: Hepatic stellate cell, Extracellular matrix, Cirrhosis, Hepatic fibrosis, Liver fibrosis, Fibrosis, Matrix metalloproteinase, Chronic liver disease

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