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In vitro SLE hematopoietic stem/progenitor cell growth of bone marrow and research of the pathogenesis

Juan Li

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Abstract

Objective To compare SLE patients′ with controls′ hematopoietic stem/progenitor cell growth of bone marrow in vitro and research on the pathogenesis of hematopoietic stem/progenitor cell.Method GM CFU,E CFU and MK CFU of 16 active SLE patients and 3 remission patients were cultured in vitro with semisolid methylcellulose.Results GM CFU,E CFU and MK CFU in active SLE were (182±50),(56±27) and (8±5),respectively,and their yield was lower than that in controls.The yield of GM CFU and E CFU in remission patients was higher than in active patients,but MK CFU had no obvious change in two groups. Conclusion Hematopoietic stem/progenitor cells of active SLE are abnormal in the functions of proliferation and differentiation.Recovery of MK CFU is later than that of GM CFU and E CFU.The abnormality of hematopoietic stem/progenitor cells may be relative to pathogenesis of SLE.

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Objective To compare SLE patients′ with controls′ hematopoietic stem/progenitor cell growth of bone marrow in vitro and research on the pathogenesis of hematopoietic stem/progenitor cell.Method GM CFU,E CFU and MK CFU of 16 active SLE patients and 3 remission patients were cultured in vitro with semisolid methylcellulose.Results GM CFU,E CFU and MK CFU in active SLE were (182±50),(56±27) and (8±5),respectively,and their yield was lower than that in controls.The yield of GM CFU and E CFU in remission patients was higher than in active patients,but MK CFU had no obvious change in two groups. Conclusion Hematopoietic stem/progenitor cells of active SLE are abnormal in the functions of proliferation and differentiation.Recovery of MK CFU is later than that of GM CFU and E CFU.The abnormality of hematopoietic stem/progenitor cells may be relative to pathogenesis of SLE.

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Available abstract

Objective To compare SLE patients′ with controls′ hematopoietic stem/progenitor cell growth of bone marrow in vitro and research on the pathogenesis of hematopoietic stem/progenitor cell.Method GM CFU,E CFU and MK CFU of 16 active SLE patients and 3 remission patients were cultured in vitro with semisolid methylcellulose.Results GM CFU,E CFU and MK CFU in active SLE were (182±50),(56±27) and (8±5),respectively,and their yield was lower than that in controls.The yield of GM CFU and E CFU in remission patients was higher than in active patients,but MK CFU had no obvious change in two groups. Conclusion Hematopoietic stem/progenitor cells of active SLE are abnormal in the functions of proliferation and differentiation.Recovery of MK CFU is later than that of GM CFU and E CFU.The abnormality of hematopoietic stem/progenitor cells may be relative to pathogenesis of SLE.

Key concepts: Progenitor cell, Haematopoiesis, Bone marrow, CFU-GM, Stem cell, Pathogenesis, Immunology, Biology

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In vitro SLE hematopoietic stem/progenitor cell growth of bone marrow and research of the pathogenesis — Research Paper | ScholarLens