2009•Chinese Journal of Hospital PharmacyRequires access

Influence mitochondrial ATP-sensitive potassium channel opener on mitochondrial functions of simulated ischemia/reperfusion injury in cultured thalamus neuron

Fei‐Hong Yao

Abstract

OBJECTIVE To investigate the affection of mitochondrial ATP-sensitive potassium channel by ischemia/reperfusion injury in cultured thalamus neuron.METHODS In model of simulated ischemia/reperfusion injury,rats were pretreated with diazoxide. The activity of mitochondria and the mitochondrial membrane potential were observed.RESULTS Compared with the controls the activity of mitochondria and the mitochondrial membrane potential were decreased in ischemia/ reperfusion group. Administration of diazoxide increased the activity of mitochondria and mitochondrial membrane potential.CONCLUSION Preconditioning by diazoxide can protect the function of mitochondria against thalamus neuron ischemia/ reperfusion injury.

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Key concepts: Diazoxide, Mitochondrion, Ischemia, Membrane potential, Potassium channel opener, Neuron, Potassium channel, Reperfusion injury