The susceptibility analysis of Klebsiella pneumoniae isolated from children with lower respiratory tract infections in Xianju County

Objective To analyze the resistant characteristics of Klebsiella pneumoniae isolated from Lower respiratory tract infection children inpatients in our hospital,and provide basis for clinical rational use of antimicrobial agents. Methods 81 cases of lower respiratory tract infection children patients infected by Klebsiella pneumoniae in People's Hospital of Xianju County from July 2012 to July 2013 were selected. Clinical general information of the children patients was analyzed. The identification of the isolates was performed,and their drug sensitivity against 18 kinds of antibiotics were detected. Statistical analysis was done by using WHONET 5. 4 software. Results The rate of ESBL-producing K. pneumoniae was 51. 85%. All strains were sensitive to imipenem,ertapenem,levofloxacin and amikacin. ESBLs-producing strains were highly resistant to cephalosporins,while the resistance rates to ciprofloxacin,piperacillin / tazobactam and Cefotetan were still lower at 2. 43%,7. 31%,and 17. 07% respectively. Non-ESBL-producing strains were significantly sensitive to cephalosporin,fluoroquinolones,and aminoglycosides,with the sensitivity rates over 80%. Conclusion The resistance of K. pneumoniae isolated from children is high in our region; Detection of pathogens should paid more attention.