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Pharmacokinetics of Extended-release Tablets of Quetiapine in Beagle Dogs by HPLC-MS/MS Method

Fang Fěng

Abstract

Objective: To establish an HPLC-MS/MS method for the determination and pharmacokinetic study of quetiapine in Beagle dogs.Methods: Six beagle dogs were randomized into two groups.A two-way crossover study was adopted.Plasma samples were collected at different time points.Plasma concentration of quetiapine was determined by HPLC-MS/MS and pharmacokinetic parameters were calculated.Results: The results indicated that the tmax and t1/2 of extended-release tablets were longer than those of immediate tablets,and the Cmax of extended-release tablets was lower than that of immediate tablets.Conclusion: The test tablets have marked sustained release characters.

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Key concepts: Beagle, Pharmacokinetics, Cmax, Crossover study, Chromatography, High-performance liquid chromatography, Plasma concentration, Quetiapine Fumarate