Use Calcium Salts Deposition Method to Establish Abdominal Aortic Aneurysm Model

Aim To study the effect of the concentration of calcium chloride on the establishment of abdominal aortic aneurysm model,and provide basis for the research on abdominal aortic aneurysm. Methods Thirty male New Zealand white rabbits were chosen and randomly divided into three groups,including experimental group one,experimental group two and control group.Their abdominal aorta were respectively underwent infiltration of 0.5 mol/L calcium chloride,0.75 mol/L calcium chloride,and physiological saline.Six weeks later,the diameter of the aorta was measured,and the aortic tissue was exercised for histological examination. Results Dilatation rate of abdominal aorta of experimental group one,experimental group two and control group was 87.31%,124.12% and 12.10% respectively.Compared with experimental group one,experimental group two had more significant destruction and degradation of elastic fiber,decrease of smooth muscle cell,and dilation of abdominal aorta. Conclusion Infiltration method with 0.75 mol/L calcium chloride is a simple,feasible method to establish rabbit abdominal aortic aneurysm model.