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2014•Journal of China Clinic Medical ImagingRequires access

Correlation study of MRS diagnosis of diffuse axonal injury with clinical prognosis

Qi Qian

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Abstract

Objective: To study the imaging features of brain diffuse axonal injury(DAI) by magnetic resonance spectroscopy(MRS), and explore the value of MRS in the diagnosis of DAI and severity assessment. Materials and Methods:Thirty patients with DAI(DAI group) and 10 healthy volunteers(control group) undertook1H-MRS scanning, to assess the metabolite levels of N-acetyl aspartic acid(NAA), choline(Cho), creatine(Cr), combined with Glasgow coma scale(GCS) and Glasgow outcome scale(GOS) score for correlation analysis. Results: Compared with control group, NAA decreased, Cho increased,NAA/Cho, NAA/Cr value decreased and Cho/Cr value increased in DAI group. The change of NAA/Cr, NAA/Cho, Cho/Cr value showed correlation with GCS and GOS in patients with DAI. Conclusion: MRS can quantitatively measure the brain tissue metabolism of patients with DAI, showing important value for the diagnosis and prognosis evaluation of the severity of DAI.

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Objective: To study the imaging features of brain diffuse axonal injury(DAI) by magnetic resonance spectroscopy(MRS), and explore the value of MRS in the diagnosis of DAI and severity assessment. Materials and Methods:Thirty patients with DAI(DAI group) and 10 healthy volunteers(control group) undertook1H-MRS scanning, to assess the metabolite levels of N-acetyl aspartic acid(NAA), choline(Cho), creatine(Cr), combined with Glasgow coma scale(GCS) and Glasgow outcome scale(GOS) score for correlation analysis. Results: Compared with control group, NAA decreased, Cho increased,NAA/Cho, NAA/Cr value decreased and Cho/Cr value increased in DAI group. The change of NAA/Cr, NAA/Cho, Cho/Cr value showed correlation with GCS and GOS in patients with DAI. Conclusion: MRS can quantitatively measure the brain tissue metabolism of patients with DAI, showing important value for the diagnosis and prognosis evaluation of the severity of DAI.

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Available abstract

Objective: To study the imaging features of brain diffuse axonal injury(DAI) by magnetic resonance spectroscopy(MRS), and explore the value of MRS in the diagnosis of DAI and severity assessment. Materials and Methods:Thirty patients with DAI(DAI group) and 10 healthy volunteers(control group) undertook1H-MRS scanning, to assess the metabolite levels of N-acetyl aspartic acid(NAA), choline(Cho), creatine(Cr), combined with Glasgow coma scale(GCS) and Glasgow outcome scale(GOS) score for correlation analysis. Results: Compared with control group, NAA decreased, Cho increased,NAA/Cho, NAA/Cr value decreased and Cho/Cr value increased in DAI group. The change of NAA/Cr, NAA/Cho, Cho/Cr value showed correlation with GCS and GOS in patients with DAI. Conclusion: MRS can quantitatively measure the brain tissue metabolism of patients with DAI, showing important value for the diagnosis and prognosis evaluation of the severity of DAI.

Key concepts: Glasgow Coma Scale, Creatine, Medicine, Diffuse axonal injury, Choline, Glasgow Outcome Scale, Internal medicine, Magnetic resonance imaging

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