ScholarLens Back to search
2011•Strait Pharmaceutical JournalRequires access

The efficacy and toxicities of cisplatin chemotherapy intraperitoneal infusion plus CTX in treatment of advanced epithelial ovarian cancer

Pan Yi-hong

Open publisher page 0 citations

Abstract

OBJECTIVE To study the efficacy and toxicities of intraperitoneal infusion plus CTX in treatment of advanced epithelial ovarian cancer.METHODS Resrospective analysis was utilized to analyze the clinical materials of 43 cases of advanced epithelial ovarian cancer in our hospital from June 2000 to June 2005.They were all recerived cisplatin chemotherapy intraperitoneal infusion plus ctx each 3~4weeks,ranging from 1~12 cycles.Analysis their response and prgnosis.RESULTS Ⅲ CR10 cases of patients,PR 14 n,SD6 cases,PD1,the ORR was 77.4%.Ⅳ patients with CR3 cases,PR5 cases,SD3 cases,PD1 cases,PR5 cases,SD3 cases,PD1 cases,the ORR was 66.7%,no significant difference between the two groups.However,Ⅲ and Ⅳ of 3-year survival rate and 5-year survival rates were significantly different.43 patients,the PFS was 21.5 months,the average survival time was 37.5 months.CONCLUSION Cisplatin chemotherapy intraperitoneal infusion plus ctx chemotherapy in ovarian cancer is effective and safe.Prognosis is related with pathological type,histological grade,postoperative residual tumor size and chemotherapy treatment.

About this research paper

What this paper is about

OBJECTIVE To study the efficacy and toxicities of intraperitoneal infusion plus CTX in treatment of advanced epithelial ovarian cancer.METHODS Resrospective analysis was utilized to analyze the clinical materials of 43 cases of advanced epithelial ovarian cancer in our hospital from June 2000 to June 2005.They were all recerived cisplatin chemotherapy intraperitoneal infusion plus ctx each 3~4weeks,ranging from 1~12 cycles.Analysis their response and prgnosis.RESULTS Ⅲ CR10 cases of patients,PR 14 n,SD6 cases,PD1,the ORR was 77.4%.Ⅳ patients with CR3 cases,PR5 cases,SD3 cases,PD1 cases,PR5 cases,SD3 cases,PD1 cases,the ORR was 66.7%,no significant difference between the two groups.However,Ⅲ and Ⅳ of 3-year survival rate and 5-year survival rates were significantly different.43 patients,the PFS was 21.5 months,the average survival time was 37.5 months.CONCLUSION Cisplatin chemotherapy intraperitoneal infusion plus ctx chemotherapy in ovarian cancer is effective and safe.Prognosis is related with pathological type,histological grade,postoperative residual tumor size and chemotherapy treatment.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

OBJECTIVE To study the efficacy and toxicities of intraperitoneal infusion plus CTX in treatment of advanced epithelial ovarian cancer.METHODS Resrospective analysis was utilized to analyze the clinical materials of 43 cases of advanced epithelial ovarian cancer in our hospital from June 2000 to June 2005.They were all recerived cisplatin chemotherapy intraperitoneal infusion plus ctx each 3~4weeks,ranging from 1~12 cycles.Analysis their response and prgnosis.RESULTS Ⅲ CR10 cases of patients,PR 14 n,SD6 cases,PD1,the ORR was 77.4%.Ⅳ patients with CR3 cases,PR5 cases,SD3 cases,PD1 cases,PR5 cases,SD3 cases,PD1 cases,the ORR was 66.7%,no significant difference between the two groups.However,Ⅲ and Ⅳ of 3-year survival rate and 5-year survival rates were significantly different.43 patients,the PFS was 21.5 months,the average survival time was 37.5 months.CONCLUSION Cisplatin chemotherapy intraperitoneal infusion plus ctx chemotherapy in ovarian cancer is effective and safe.Prognosis is related with pathological type,histological grade,postoperative residual tumor size and chemotherapy treatment.

Key concepts: Cisplatin, Medicine, Chemotherapy, Ovarian cancer, Epithelial ovarian cancer, Stage (stratigraphy), Internal medicine, Pathological

Back to paper searchBrowse research topicsOriginal source
The efficacy and toxicities of cisplatin chemotherapy intraperitoneal infusion plus CTX in treatment of advanced epithelial ovarian cancer — Research Paper | ScholarLens