A comparative trial of clomipramine and amitriptyline in seventy depressive disorder patients

This paper reports a control study of clomipramine (M 21, F 14, age 33±11 yr) and amitriptyline (M 16, F 19, age 33±12 yr) for treatment on seventy depressive patients. By gradual increase of the dose to 150-250 mg/d within 1 wk for. 4 wk, the results showed that clomipramine had better antidepressive efficacy than amitriptyline, but without statistical significance. The decrease of HDS total scores of clomipramine and amitriptyline were 29±9 and 24±13 respectively, P0.05. The common side effects of both drugs are anticholinergic effects, and clomipramine has lesser adverse reactions than amitriptyline.