ScholarLens Back to search
2006•Qilu yixue zazhiRequires access

ANTIOXIDANT EFFECT OF NIMODIPINE ON RATS WITH EPILEPSY INDUCED BY PENTETRAZOLE

Xie A

Open publisher page 0 citations

Abstract

ObjectiveTo explore the antioxidant role of nimodipine in experimental-epilepsy rats.MethodsFifty Wistar rats were divided into 5 groups: control group,epilepsy group,and 0.1 mg-,0.3 mg-,and 0.5 mg-nimodipine groups.The incubation period,duration,and the onset of epilepsy were observed and SOD,MDA,and GSH-PX of brain tissue were determined in the nimodipine group.The results were compared with those of the PTZ epilepsy group.ResultsThe onset in nimodipine-pretreatment group was characterized by light seizure,prolonged incubation time,short duration and high SOD, low MDA and GSH-PX.There were significantly difference between them(F=10.720-35.831,P0.01).ConclusionAntiepileptic role of nimodipine may be achieved by its antioxidation.

About this research paper

What this paper is about

ObjectiveTo explore the antioxidant role of nimodipine in experimental-epilepsy rats.MethodsFifty Wistar rats were divided into 5 groups: control group,epilepsy group,and 0.1 mg-,0.3 mg-,and 0.5 mg-nimodipine groups.The incubation period,duration,and the onset of epilepsy were observed and SOD,MDA,and GSH-PX of brain tissue were determined in the nimodipine group.The results were compared with those of the PTZ epilepsy group.ResultsThe onset in nimodipine-pretreatment group was characterized by light seizure,prolonged incubation time,short duration and high SOD, low MDA and GSH-PX.There were significantly difference between them(F=10.720-35.831,P0.01).ConclusionAntiepileptic role of nimodipine may be achieved by its antioxidation.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

ObjectiveTo explore the antioxidant role of nimodipine in experimental-epilepsy rats.MethodsFifty Wistar rats were divided into 5 groups: control group,epilepsy group,and 0.1 mg-,0.3 mg-,and 0.5 mg-nimodipine groups.The incubation period,duration,and the onset of epilepsy were observed and SOD,MDA,and GSH-PX of brain tissue were determined in the nimodipine group.The results were compared with those of the PTZ epilepsy group.ResultsThe onset in nimodipine-pretreatment group was characterized by light seizure,prolonged incubation time,short duration and high SOD, low MDA and GSH-PX.There were significantly difference between them(F=10.720-35.831,P0.01).ConclusionAntiepileptic role of nimodipine may be achieved by its antioxidation.

Key concepts: Nimodipine, Epilepsy, Medicine, Antioxidant, Anesthesia, Incubation, Incubation period, Brain tissue

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
ANTIOXIDANT EFFECT OF NIMODIPINE ON RATS WITH EPILEPSY INDUCED BY PENTETRAZOLE — Research Paper | ScholarLens