The time selection of high volume continuous veno-venous hemofiltration in the treatment of severe acute pancreatitis

Objective To explore the time selection of high volume continuous veno-venous hemofiltration(HV-CVVH) in the treatment of severe acute pancreatitis(SAP).Methods Twenty-four patients suffered from SAP were randomly divided into three groups: group Ⅰwith the treatment of HV-CVVH for 8h(n=8),group Ⅱ with the treatment for 16h(n=8) and group Ⅲ with the treatment for 24h(n=8).The patients in three groups underwent the treatment of HV-CVVH for 5～10 days.The plasma levels of tumor necrosis factor-α(TNF-α),interleukin-1(IL-1),IL-6,the APACHEⅡscores and cure rate were measured before and after the treatment.Results After the treatment of HV-CVVH,the hemodynamic parameters of patients were apparently improved,and the APACHEⅡscores were decreased.The levels of TNF-a,IL-1 and IL-6 were decreased after the treatment of HV-CVVH,and then reached the lowest point 8h later.The levels of TNF-a,IL-1 and IL-6 in the three groups were gradually increased to normal level.The APACHEⅡscores and cure rate had no significant difference between the three groups(P0.05).Conclusion HV-CVVH is effective in the treatment of severe acute pancreatitis.For SAP patients who are suit for the hemofiltration treatment,the treatment of HV-CVVH for 8h and for more than 8h has nearly the same effectiveness.