2009•Unpublished venueRequires access

Effect and mechanism of arsenic trioxide (As_2O_3) on MRP mRNA expression on human gastric carcinoma cells in vitro

BO Wan-lan

Abstract

Objective:To study the apoptosis and mechanism of As2O3 on human gastric carcinoma cells.Methods:MTT FCM and RT-PCR tests were used to investigate apoptosis levels induced by arsenic trioxide and the effect on MRP mRNA expression.Results:1.0μmol/L and 2.0μmol/l arsenic trioxide can decrease MRP mRNA expression.Conclusion:Low concentrations As2O3 may improve apoptosis of gastric cancer by decreasing MRP mRNA expression.

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Key concepts: Arsenic trioxide, Apoptosis, Messenger RNA, Gastric carcinoma, In vitro, Chemistry, Trioxide, Arsenic