Role of Hypertonic Saline in Treatment of Ischemic Cerebral Infarction

Objective:To compare with the effects of hypertonic saline and mannitol on isehemic cerebral infarction. Methods: Forty six patients were randomly divided into three groups. In addition to normal therapy, group A, B and C was intravenously injected with 7.5% hypertonic saline,10% hypertonic saline and 20% mannitol for 6 days, respectively. During the therapy, plasma electrolytes, renal function and neurologic impairment score were measured. Result: Neurologic impairment was greatly improved in all three groups. In group C, the injury of renal function could also be detected, which didn't occur in group A and B. Conclusion: Compared with mannitol in dehydration, hypertonic saline has no obvious nephrotoxicity and may provide a better choice in treatment of isehemic cerebral infarction.