Diagnosis value of minimum exercise test of lactic acid and pyruvic acid for mitochondrial myopathy

Objective To investigate the diagnosis value of minimum exercise test of lactic acid and pyruvic acid(METLP) for mitochondrial myopathy.Methods METLP were applied in 21 patients with mitochondrial myopathy,6 patients with other myopathy and 14 patients without myopathy.All of them were diagnosed by muscle biopsy.The results of METLP were analyzed.Results The abnormal results of METLP were found in 18(85.7%) patients with mitochondrial myopathy,including 12 cases had 2 or more abnormal indexes.The mainly abnormal index was the value of lactic acid post-exercise/ pyruvic acid pre-exercise(L2/P1) 17.The abnormal results of METLP were found in 6(100%) patients with other myopathy.Most of them showed a high concentration of lactic acid post-aerobic exercise(L2),and sustainable to after rest,or even more higher(L3).3(21.4%)patients without myopathy showed abnormal results of METLP.Conclusions In all the indexes of METLP,the value of L2/P1 is the reliable index for diagnosis mitochondrial myopathy or no-myopathy;the value of L3/L2 is the most important index in differential diagnosis of mitochondrial myopathy and other myopathy.METLP plays a certain role in the diagnosis of the mitochondrial myopathy,but the clinical and pathological data ought to be combined.