Expressions of phosphorylated AKT and phosphorylated EGFR in non-small cell lung cancer and their significance

Objective:To evaluate the expressions of phosphorylated epidermal growth factor receptor(p-EGFR) and its downstream molecule phosphorylated AKT(p-AKT) in non-small cell lung cancer(NSCLC)and their significance.Methods:The immunhistochemistry was used to detect the expressions of p-AKT and p-EGFR proteins in 95 cases of NSCLC tissues.The relationship between the p-AKT and p-EGFR and between their expression and prognosis were also evaluated.Results:The positive rate of p-EGFR was 57.89%(55/95) and was related with age,gender and histological type(P=0.008,P=0.003,P=0.009).The positivity of p-EGFR was higher in young group(33/46),female group(24/30),and adenocarcinoma group(35/52).The positive rate of p-AKT was 66.32%(63/95) and was related with differentiation,lymph node metastasis and tumor size(P=0.036,P=0.047,P=0.017,res-pectively).The positivity of p-AKT was higher in low differentiation group(20/23),lymph node metastasis group(29/37),and tumor diameter ≤3 cm group(36/46).Univariate analysis showed that the expressions of p-AKT and p-EGFR were not associated with prognosis(P=0.854,P=0.729).Multivariate analysis showed that neither p-AKT nor p-EGFR was correlated with the patients' survival time(P=0.497,P=0.731).The p-AKT was positively correlated to the p-EGFR(r=0.204,P=0.047).Conclusion:The expressions of p-AKT and p-EGFR had no impact on the prognosis of NSCLC.They can not serve as prognostic indicators for NSCLC.