Clinical and Pathological Analysis in 80 Patients with Henoch-Schnlein Purpura Nephritis

Objective We analysed the materials of 80 patients with Henoch-Schnlein purpura nephritis(HSPN) to study the relationship between the clinical and pathological characteristics.Methods We retrospectively reviewed the clinical and pathological information of 80 patients with HSPN.Results A majority of patients(68.75%) appeared nephritis within a month after the purpura.33.75% of the patients had evidences of preceding infections.The most common clinical manifestition is hematuria and proteinuria group(35 cases,43.75%),and secondly nephrotic syndrome group(28 cases,35%)and thirdly acute nephtitis group(13 cases,16.25%).Solitary hematuria or proteinuria group has only 3 cases(3.75%),and rapidly progressive glomerulonephritis(RPGN) group has only one case.The most common pathological classification was gradeⅡ(29 cases,36.25%),secondly grade Ⅲ(25 cases,31.25%).The rest in a descending order are grade VI(13 cases,16.25%),grade I( 7 cases,8.75%),grade IV(3 cases,3.75%),grade V(3 cases,3.75%).The immune complexes mainly deposit on the glomerular mesangium and 53.75% of the deposition is simply IgA.Conclusion The pathological changes of HPSN patients are mainly grade Ⅱand Ⅲ,and the clinical manifestations are closely associated with pathological classification(P = 0.05 ).Patients with more serious clinical manifestitions have more serious pathological changes.However,clinical manifestitions have no relationship with immune complex deposition(P 0.05).