2010•Academic Journal of Second Military Medical UniversityRequires access

Interferon-gamma and systemic lupus erythematosus

Su Xiao

Abstract

The etiology and pathogenesis of systemic lupus erythematosus( SLE) remain unclear. Interferon-γ ( IFN-γ) ,a Th1-type cytokine,may be involved in the pathogenesis and inflammatory process of SLE. This article reviews reports on the serum IFN-γ of SLE patients and mouse SLE models,in vitro secreted IFN-γ,expression of IFN-γ induced protein and IFN-γ related genes,and treatment with traditional Chinese medicines.

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Key concepts: Pathogenesis, Immunology, Cytokine, Medicine, Interferon, Etiology, Interferon gamma, Lupus erythematosus