The Role of IL-6 Expression in Secondary Neuronal Injury and Brain Edema following Experimental Intracerebral Hemorrhage in Rat

Objective To explore the role of IL-6 expression in the brain injury and brain edema formation of intracerebral hemorrhage.Methods 24 SD rats were random classified into intracerebral hemorrhage (ICH) group and sham group.A medium volume of hematoma was formed by stereotactic infusing 50 μl autologous caudate artery blood into the right basal ganglia of rat.Rats were decapitated for testing the brain water content and immunohistochemistory staining,Nissl staining at 6 h,24 h,48 h,72 h.And the result was statistically dealt with.Results Brain water content peaked at 48 h.There was statistic difference between the ICH group and the sham group (P0.05).In ICH group,the expression of IL-6 in the rat brain peaked at 48 h too,higher than the control group significantly (P0.01).In ICH group,the intact neuronal numbers surrounding hematoma and in hippocampus were least at 72 h,lower than the control group evidently (P0.01).Conclusion The high expression of IL-6 in rat brain after ICH contributed to the brain edema formation and the secondary neuronal injury .