Value of High-Risk Human Papillomavirus Test in Clinical Triage of Patients with Atypical Squamous Cells of Undetermined Significance

Objective To explore the value of high-risk human papilloma virus(HR-HPV) test in clinical triage of patients with atypical squamous cells of undetermined significance(ASCUS).Methods All 165 patients with ASCUS received cervical tissue biopsy under colposcopy and HR-HPV test;the cervical lesions were analyzed and compared between patients with positive HR-HPV and those with negative HR-HPV.Results ①there was 4 cases(2.42%) with early cervical cancer,37 cases(22.4%) with CIN Ⅰ,29 cases(17.6%) with CINⅡ,9 cases(5.45%) with CIN Ⅲ and 86 cases(52.1%) with cervical inflammation in 165 patient s with ASCUS.②The HR-HPV infection positive rate was 57.6%(95/165),infection types was HPV16,52,58,18 and CP8304 in order.③there was 36 cases(37.9%) with CIN Ⅱ and above in cases with positive HR-HPV,higher than in those with negative HR-HPV(6 cases,accounting for 8.57%),there was a significant difference(P0.01).4 cases with early cervical cancer were all positive with HR-HPV,among those 2 cases with HPV16,and 1 case with HPV58 and 1 case HPV18.Conclusion High grade cervical intraepithelial neoplasia and early cervical cancer are closely correlated to HR-HPV infection;HPV16 and HPV52 are the most common types.HR-HPV test can triage effectively in patients with ASCUS detected by TCT.