Effects of e99 yolk and moctamide on serum lipids in man

Forty‐one healthy male volunteers received 9 egg yolks daily in addition to their ordinary meals for 14 days. Mean elevation of serum cholesterollevels was 21,6 mg per 100 ml (11.4%) of the initial level. Middle‐aged men (40 to 45) showed more elevation of serum cholesterollevel than young men (18 to 20). After the first egg yolk fee ding period, 6 young men and 3 middle‐aged men, whose serum cholesterol levels increased by more than 10%, were selected to examine the etfect of moctamide on dietary hypercholesterolemia. They were given a daily oral dose of 300 mg of moctamide during the second egg yolk feeding period of 2 weeks, which was started 4 to 8 weeks after the end of the first period. In the third period, they were given 150 mg per day of moctamide in the same way. Daily doses of 300 mg of moctamide completely inhibited the elevation of serum cholesterol, while 150 mg suppressed it significantly.