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2016•International Journal of Clinical Pharmacology and TherapeuticsRequires access

Warfarin dose requirement with different genotypes of polymorphisms on CYP2C9 and VKORC1 and indications in Han-Chinese patients

Weirong Chen, Luhua Wu, Xin Liu, Yue Shen, Yan Liang, Jun Zhu, Huiqiong Tan, Yanmin Yang, Qun Liu, Ming‐Sheng Wang, Lisheng Liu, Xingyu Wang

Open publisher page 10 citations

Abstract

AIMS: have different effects on the dose of warfarin in 180 Han Chinese patients who were recruited from the Fu Wai Hospital. All were on maintenance treatment with stable daily warfarin doses for a period of at least 3 months. METHODS: . RESULTS: were not dependent on the medical indication(s) present. CONCLUSIONS: , and age are significant determinants of the maintenance dose of warfarin. The medical indications atrial fibrillation, valve replacement, or a combination of both are not determinants of the warfarin dose requirements.

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What this paper is about

AIMS: have different effects on the dose of warfarin in 180 Han Chinese patients who were recruited from the Fu Wai Hospital. All were on maintenance treatment with stable daily warfarin doses for a period of at least 3 months. METHODS: . RESULTS: were not dependent on the medical indication(s) present. CONCLUSIONS: , and age are significant determinants of the maintenance dose of warfarin. The medical indications atrial fibrillation, valve replacement, or a combination of both are not determinants of the warfarin dose requirements.

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Available abstract

AIMS: have different effects on the dose of warfarin in 180 Han Chinese patients who were recruited from the Fu Wai Hospital. All were on maintenance treatment with stable daily warfarin doses for a period of at least 3 months. METHODS: . RESULTS: were not dependent on the medical indication(s) present. CONCLUSIONS: , and age are significant determinants of the maintenance dose of warfarin. The medical indications atrial fibrillation, valve replacement, or a combination of both are not determinants of the warfarin dose requirements.

Key concepts: VKORC1, CYP2C9, Warfarin, Maintenance dose, Atrial fibrillation, Medicine, Genotype, Dose

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Warfarin dose requirement with different genotypes of polymorphisms on CYP2C9 and VKORC1 and indications in Han-Chinese patients — Research Paper | ScholarLens