in the cervical spinal cord in patients with monosegmental chronic cervical myelopathy

Objective The aim of this preliminary report was to assess glu- cose metabolism in the cervical spine of patients with chronic compressive myelopathy by using FDG PET. Methods Ten patients with monoseg- mental chronic degenerative stenosis and local cord compression of the upper/middle cervical spine with signs of myelopathy on MRI and 10 control patients without known cer- vical abnormalities were investigated by FDG PET. Maximum standardised uptake values (SUVmax) were meas- ured at all levels of the cervical spine (C1-C7). Results While the controls showed the typical pattern of homo- geneous linear FDG uptake along the entire cervical cord, the patients with chronic compressive myelopathy had a normal glucose utilisation only above the level of stenosis and a significant decrease in FDG uptake below their individual level of cord compression. This may be caused by atrophy of anterior grey horn cells and the loss of glucose-consuming neurons below the level of cord compression. Conclusion FDG PET of the spine of patients with chronic compressive myelopathy may be helpful to determine the stage and severity of cervical myelopathy.