How Useful Is Classification of Lower Motor Neuron Disease

Amyotrophic lateral sclerosis (ALS) is the most common sporadic motor neuron disorder. To clinically diagnose ALS, both upper motor neuron (UMN) and lower motor neuron (LMN) abnormalities, distributed throughout the neuraxis, must be discerned. A minority of patients present with only LMN signs, and most of these patients will ultimately develop UMN abnormalities. Nonetheless, a subgroup of slowly …