Effect of puerarin on plasma MDA, SOD in rabbits following cerebral ischemia-reperfusion

Objective It is to observe the influence of puerarin on plasma malondialdehyde(MDA),superoxide dismutase(SOD) in rabbits following cerebral ischemia-reperfusion injury.Methods 24 rabbits were randomly divided into sham operation group(group A,n=8),ischemia-reperfusion group(group B,n=8) and puerarin group(group P,n=8) with whole cerebral ischemia induced by clipping of bilateral external,internal carotid arteries and vertebral arteries for 30 min and then with the reperfusion lasting 4 hours.Group P with puerarin(5mg/kg) 10 min before occlusion and followed 150?g/(kg·min) intravenously till the end of procedure.The levels of plasma MDA and SOD were assayed 15 min before occlusion(T0) and 4 hours after reperfusion(T4).Results Compared with the group A,the levels of MDA were increased and the levels of SOD were decreased significantly in group B(P all 0.01).Compared with the group B,the levels of MDA were increased,and the levels of SOD were decreased significantly in Group P(P all0.01).Conclusion Puerarin can attenuate the brain reperfusion injury,through suppresses the production of MDA,and improves SOD activity.